{"id":20,"date":"2018-08-31T08:43:31","date_gmt":"2018-08-31T08:43:31","guid":{"rendered":"http:\/\/fertiga.com\/?page_id=20"},"modified":"2026-06-04T10:12:33","modified_gmt":"2026-06-04T08:12:33","slug":"increased-live-birth-rate-2","status":"publish","type":"page","link":"https:\/\/fertiga.com\/it\/increased-live-birth-rate-2\/","title":{"rendered":"Per gli operatori sanitari"},"content":{"rendered":"<\/p>\n<p class=\"has-text-align-center\"><em>Non tutti gli ovociti sono uguali... ma ora puoi capire quali avranno maggiori probabilit\u00e0 di svilupparsi.<\/em><\/p>\n<p>\n\n\n<p class=\"wp-block-paragraph\">Aurora niPCT\u2122 \u00e8 il primo <strong>test non invasivo<\/strong> clinicamente validato che analizza ci\u00f2 che conta davvero: il potenziale biologico dell'ovocita stesso. Analizzando le cellule del cumulo ooforo che circondano e sostengono naturalmente l'ovulo, Aurora niPCT\u2122 decodifica i segnali molecolari con il pi\u00f9 alto potenziale. A differenza delle valutazioni basate su immagini o colture, <strong>non fa supposizioni, ma misura<\/strong>. A differenza dei test genetici invasivi, <strong>non provoca alcun danno<\/strong>. E a differenza di molti strumenti emergenti, \u00e8 gi\u00e0 <strong>validato nella pratica clinica<\/strong>, dove ha aumentato significativamente i tassi di gravidanza e di nati vivi gi\u00e0 al primo trasferimento.<\/p>\n\n\n\n<h2 class=\"wp-block-heading has-text-align-center\">La <strong>precisione di Aurora niPCT\u2122 per una nascita viva<\/strong> per pazienti stimolate con<\/h2>\n\n\n\n<div class=\"stats-container\">\n  <div class=\"stat-item\">\n    <div class=\"stat-box\">\n      <span class=\"stat-text\">hMG <span class=\"small-brackets\">(ad esempio Menopur, Meriofert)<\/span><\/span>\n      <span class=\"stat-bubble\">\n        80%*\n        <svg class=\"bubble-ring\" viewbox=\"0 0 100 100\">\n          <circle cx=\"50\" cy=\"50\" r=\"48\" stroke=\"#528C9E\" stroke-width=\"4\" fill=\"none\"\/>\n        <\/svg>\n      <\/span>\n    <\/div>\n  <\/div>\n  <div class=\"stat-item\">\n    <div class=\"stat-box\">\n      <span class=\"stat-text\">rFSH <span class=\"small-brackets\">(ad esempio Gonal-F, Rekovelle, Bemfola, Puregon)<\/span><\/span>\n      <span class=\"stat-bubble\">\n        70%**\n        <svg class=\"bubble-ring\" viewbox=\"0 0 100 100\">\n          <circle cx=\"50\" cy=\"50\" r=\"48\" stroke=\"#528C9E\" stroke-width=\"4\" fill=\"none\"\/>\n        <\/svg>\n      <\/span>\n    <\/div>\n  <\/div>\n  <div class=\"stat-item\">\n    <div class=\"stat-box\">\n      <span class=\"stat-text\">rFSH+rLH <span class=\"small-brackets\">(Pergoveris)<\/span><\/span>\n      <span class=\"stat-bubble\">\n        88%**\n        <svg class=\"bubble-ring\" viewbox=\"0 0 100 100\">\n          <circle cx=\"50\" cy=\"50\" r=\"48\" stroke=\"#528C9E\" stroke-width=\"4\" fill=\"none\"\/>\n        <\/svg>\n      <\/span>\n    <\/div>\n  <\/div>\n<\/div>\n\n<!-- New description box -->\n<div class=\"description-box\">\n  <p>\n    * dopo aver analizzato cellule cumuliformi di &gt; 1000 ovociti (Van Vaerenbergh et al., 2021; Adriaenssens et al., 2019); ** dopo aver analizzato cellule cumuliformi di &gt; 1000 ovociti (Adriaenssens et al., 2025).\n  <\/p>\n<\/div>\n\n<style>\n.stats-container {\n  display: flex;\n  flex-direction: column;\n  gap: 25px;\n  max-width: 650px;\n  margin: 50px auto;\n}\n\n.stat-item {\n  display: flex;\n  justify-content: center;\n}\n\n.stat-box {\n  position: relative;\n  display: flex;\n  align-items: center;\n  height: 60px;\n  background: linear-gradient(to right, #F4AD31 0%, rgba(244,173,49,0) 100%);\n  border-radius: 15px;\n  padding: 0 20px;\n  width: 75%;\n  max-width: 500px;\n}\n\n.stat-text {\n  font-size: 20px;\n  font-weight: bold;\n  color: #333;\n  line-height: 30px;\n  flex: 1;\n}\n\n\/* Smaller font for text in brackets *\/\n.small-brackets {\n  font-size: 14px;\n  font-weight: normal;\n  color: #555;\n}\n\n.stat-bubble {\n  position: absolute;\n  right: -25px;\n  top: 50%;\n  transform: translateY(-50%);\n  width: 80px;\n  height: 80px;\n  background-color: white;\n  color: #528C9E;\n  font-size: 24px;\n  font-weight: bold;\n  display: flex;\n  justify-content: center;\n  align-items: center;\n  border-radius: 50%;\n  box-shadow: 0 2px 6px rgba(0,0,0,0.2);\n}\n\n.bubble-ring {\n  position: absolute;\n  top: 0;\n  left: 0;\n  width: 100%;\n  height: 100%;\n  pointer-events: none;\n}\n\n.description-box {\n  max-width: 500px;\n  margin: -45px auto 0; \/* closer to stats *\/\n  padding: 8px 12px;\n  border-radius: 0 0 12px 12px; \/* rounded only at bottom *\/\n  text-align: center;\n  font-size: 11px;\n  color: #333;\n  background-color: #fff;\n}\n<\/style>\n\n\n<h2 class=\"wp-block-heading\">Risultati dei nostri studi<\/h2>\n<p><strong>Aumento del tasso di nati vivi<\/strong> <strong>e del<\/strong> <strong>tasso di gravidanze cliniche per SET<\/strong><\/p>\n<figure class=\"wp-block-image alignright size-full is-resized\"><a href=\"https:\/\/fertiga.com\/wp-content\/uploads\/2025\/09\/D3-and-D5.png\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-1039 alignleft\" src=\"https:\/\/fertiga.com\/wp-content\/uploads\/2025\/09\/D3-and-D5.png\" alt=\"clinical pregnancy rate increased significantly from 27 % to 63 % in the first fresh transfer cycle. Compared to day 5 SET \u2014 from 43 % to 63 %. Moreover, significant increase in live birth rate was proven between day 3 transfers.\" width=\"289\" height=\"222\" srcset=\"https:\/\/fertiga.com\/wp-content\/uploads\/2025\/09\/D3-and-D5.png 962w, https:\/\/fertiga.com\/wp-content\/uploads\/2025\/09\/D3-and-D5-300x230.png 300w, https:\/\/fertiga.com\/wp-content\/uploads\/2025\/09\/D3-and-D5-768x588.png 768w, https:\/\/fertiga.com\/wp-content\/uploads\/2025\/09\/D3-and-D5-16x12.png 16w\" sizes=\"auto, (max-width: 289px) 100vw, 289px\" \/><\/a>\n<figcaption class=\"wp-element-caption\">Studio sui risultati ottenuti da pazienti sottoposte a trasferimento elettivo di singolo embrione (eSET) e ICSI.<\/figcaption>\n<\/figure>\n<p>I risultati del nostro pi\u00f9 recente studio interventistico prospettico hanno dimostrato che nel braccio di test Aurora niPCT\u2122 (anche chiamato Aurora Test) con trasferimento di singolo embrione (SET) al giorno 3, il <strong>tasso di gravidanza clinica \u00e8 aumentato significativamente <\/strong>dal 27% al 63% nel primo ciclo di trasferimento di embrioni freschi. Rispetto al SET al giorno 5, l'aumento \u00e8 stato dal 43% al 63%. Inoltre, <strong>\u00e8 stato rilevato un tasso di nati vivi significativamente pi\u00f9 elevato<\/strong> tra i trasferimenti al giorno 3. Si trattava di pazienti sottoposte a ICSI stimolate con HP-hMG. Nei bracci di controllo, le pazienti sono state sottoposte solo a valutazione morfologica. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30627993\/\" target=\"_blank\" rel=\"noreferrer noopener\">Leggi di pi\u00f9\u2026<\/a><\/p>\n<p>&nbsp;<\/p>\n<p><strong>Aumento del tasso cumulativo di gravidanze<\/strong><\/p>\n<p>In uno studio clinico precedente, sono stati monitorati i tassi cumulativi e il test Aurora niPCT\u2122 ha <strong>aumentato significativamente il tasso di gravidanza cumulativo<\/strong> dal 56% al 78% rispetto al gruppo di controllo del terzo giorno, quando la paziente si \u00e8 sottoposta a cicli consecutivi. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33608027\/\" target=\"_blank\" rel=\"noreferrer noopener\">Leggi di pi\u00f9\u2026<\/a><\/p>\n<p>&nbsp;<\/p>\n<p><strong>Aumento del tasso di gravidanze al primo tentativo e riduzione del tempo necessario per concepire.<\/strong><\/p>\n<p>&nbsp;<\/p>\n\n<div class=\"wp-block-image\">\n<figure class=\"alignright size-full is-resized\"><a href=\"https:\/\/fertiga.com\/wp-content\/uploads\/2025\/10\/time-to.png\"><img loading=\"lazy\" decoding=\"async\" width=\"822\" height=\"758\" src=\"https:\/\/fertiga.com\/wp-content\/uploads\/2025\/10\/time-to.png\" alt=\"Results of clinical study showed a significantly shorter time-to-pregnancy. \" class=\"wp-image-1296\" style=\"width:300px;height:auto\" srcset=\"https:\/\/fertiga.com\/wp-content\/uploads\/2025\/10\/time-to.png 822w, https:\/\/fertiga.com\/wp-content\/uploads\/2025\/10\/time-to-300x277.png 300w, https:\/\/fertiga.com\/wp-content\/uploads\/2025\/10\/time-to-768x708.png 768w, https:\/\/fertiga.com\/wp-content\/uploads\/2025\/10\/time-to-13x12.png 13w\" sizes=\"auto, (max-width: 767px) 89vw, (max-width: 1000px) 54vw, (max-width: 1071px) 543px, 580px\" \/><\/a><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n<p>I risultati del nostro studio clinico hanno mostrato un <strong>tempo di concepimento significativamente pi\u00f9 breve<\/strong> nel gruppo sottoposto al test Aurora niPCT\u2122 con trasferimento di un singolo embrione fresco o congelato rispetto al gruppo di controllo. Considerando tutte le pazienti con almeno due embrioni trasferibili, nel gruppo di controllo sono stati necessari tre trasferimenti aggiuntivi per ottenere la stessa gravidanza clinica.\u00a0 <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33608027\/\" target=\"_blank\" rel=\"noreferrer noopener\">Leggi di pi\u00f9\u2026<\/a><\/p>\n<p>&nbsp;<\/p>\n\n\n<h2 class=\"wp-block-heading\">Principio basato sulla scienza<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Il test Aurora niPCT\u2122 viene eseguito sulle cellule del cumulo ooforo che circondano gli ovociti della paziente e si basa sulla misurazione dell'espressione di geni specifici. <strong>Le cellule del cumulo vengono rimosse singolarmente<\/strong> da ciascun ovocita e l'RNA viene estratto da esse. Viene eseguita una PCR in tempo reale per i geni predittivi e due geni di controllo, che porta a una classificazione quantitativa di tutti gli ovociti. Scopri di pi\u00f9:<\/p>\n\n\n\n<div class=\"wp-block-file\"><a id=\"wp-block-file--media-1391f922-c552-481c-8f3b-96cfcf582df5\" href=\"https:\/\/fertiga.com\/wp-content\/uploads\/2026\/06\/Aurora-niPCT-Brochure.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">Aurora niPCT\u2122 Brochure ENG<\/a><\/div>\n\n\n\n<div class=\"wp-block-file\"><a id=\"wp-block-file--media-a6e48bad-241e-431c-97b6-86414e58f440\" href=\"https:\/\/fertiga.com\/wp-content\/uploads\/2026\/06\/DU-niPCT-Brochure_clinicians.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">Aurora niPCT\u2122 Brochure NL<\/a><\/div>\n\n\n\n<div class=\"wp-block-file\"><a id=\"wp-block-file--media-607f2cae-6e75-4bf4-9a98-d2af80f53753\" href=\"https:\/\/fertiga.com\/wp-content\/uploads\/2026\/06\/FR-niPCT-Brochure_clinicians.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">Aurora niPCT\u2122 Brochure FR<\/a><\/div>\n\n\n\n<h1 class=\"wp-block-heading\">Aurora niPCT\u2122 \u00e8 applicabile per<\/h1>\n\n\n\n<ul class=\"wp-block-list\">\n<li>trasferimento freschi<\/li>\n\n\n\n<li>trasferimenti congelati<\/li>\n\n\n\n<li>cicli di donazione<\/li>\n\n\n\n<li>crioconservazione degli ovociti<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Il test Aurora niPCT\u2122 viene eseguito sulle cellule del cumulo ooforo di tutti gli ovociti di una paziente e segue la stessa procedura di analisi molecolare prevista per la ICSI. Gli ovociti vengono classificati e, in futuro, quelli con il punteggio pi\u00f9 alto possono essere utilizzati per primi. Gli ovociti devono essere congelati singolarmente. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38295095\/\" target=\"_blank\" rel=\"noreferrer noopener\">Leggi di pi\u00f9<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Tempistiche del servizio Aurora niPCT\u2122<\/h2>\n\n\n<div class=\"wp-block-image wp-block-image aligncenter size-large\">\n<figure ><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"345\" src=\"https:\/\/fertiga.com\/wp-content\/uploads\/2026\/05\/Yellow-and-Orange-Illustrative-Self-Improvement-Infographic-Poster-1-1-1024x345.png\" alt=\"\" class=\"wp-image-1641\" srcset=\"https:\/\/fertiga.com\/wp-content\/uploads\/2026\/05\/Yellow-and-Orange-Illustrative-Self-Improvement-Infographic-Poster-1-1-1024x345.png 1024w, https:\/\/fertiga.com\/wp-content\/uploads\/2026\/05\/Yellow-and-Orange-Illustrative-Self-Improvement-Infographic-Poster-1-1-300x101.png 300w, https:\/\/fertiga.com\/wp-content\/uploads\/2026\/05\/Yellow-and-Orange-Illustrative-Self-Improvement-Infographic-Poster-1-1-768x259.png 768w, https:\/\/fertiga.com\/wp-content\/uploads\/2026\/05\/Yellow-and-Orange-Illustrative-Self-Improvement-Infographic-Poster-1-1-18x6.png 18w, https:\/\/fertiga.com\/wp-content\/uploads\/2026\/05\/Yellow-and-Orange-Illustrative-Self-Improvement-Infographic-Poster-1-1.png 1536w\" sizes=\"auto, (max-width: 767px) 89vw, (max-width: 1000px) 54vw, (max-width: 1071px) 543px, 580px\" \/><figcaption class=\"wp-element-caption\">Timetable for a fresh eSET<\/figcaption><\/figure>\n<\/div>\n\n<\/p>\n<p><!-- \/wp:post-content --><\/p>\n<p><!-- wp:paragraph --><\/p>\n<p>Qualora non si verifichi una gravidanza al primo trasferimento, gli embrioni soprannumerari, vitrificati singolarmente, verranno trasferiti in base al punteggio Aurora.<\/p>\n<p><!-- \/wp:paragraph --><\/p>\n<p><!-- wp:paragraph --><\/p>\n<p>Se \u00e8 previsto un eSET con campioni congelati, questi possono essere spediti in un secondo momento, ma devono pervenire al laboratorio di analisi cliniche di Fertiga almeno una settimana prima del trasferimento.<\/p>\n<p><!-- \/wp:paragraph --><\/p>\n<p><!-- wp:file {\"id\":1594,\"href\":\"https:\/\/fertiga.com\/wp-content\/uploads\/2026\/04\/Blue-and-White-Modern-Pharmacy-Lab-Flyer-7.pdf\",\"showDownloadButton\":false,\"displayPreview\":false,\"previewHeight\":670} --><\/p>\n<div class=\"wp-block-file\"><a id=\"wp-block-file--media-a2751fe1-b2a3-41ed-a0e0-3f5eb5fdbc22\" href=\"https:\/\/fertiga.com\/wp-content\/uploads\/2026\/04\/Blue-and-White-Modern-Pharmacy-Lab-Flyer-7.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">Un opuscolo pi\u00f9 dettagliato sul flusso di lavoro del laboratorio di embriologia. <\/a><\/div>\n<p><!-- \/wp:file --><\/p>\n<p><!-- wp:paragraph --><\/p>\n<p>Se desideri maggiori informazioni sulla <strong>standardizzazione delle condizioni preanalitiche per test preimpianto non invasivi affidabili sulle cellule del cumulo<\/strong>, <a href=\"https:\/\/fertiga.com\/it\/contact-us\/\" type=\"link\" id=\"https:\/\/fertiga.com\/contact-us\/\">, contattaci<\/a> per un white paper.<\/p>\n<p><!-- \/wp:paragraph --><\/p>\n<p><!-- wp:heading --><\/p>\n<h2 class=\"wp-block-heading\">La nostra ricerca<\/h2>\n<p><!-- \/wp:heading --><\/p>\n<p><!-- wp:list {\"ordered\":true} --><\/p>\n<ol class=\"wp-block-list\"><!-- wp:list-item --><\/p>\n<li>Adriaenssens T, Van Vaerenbergh I, Van Leuven W, Coucke W, Montenegro S, Zheng W, D\u2019Hooghe T, Van Landuyt L, De Munck N, Van Hecke E, Smitz J, Rosenthal A, Blockeel C<em>.<\/em>Live birth in patients stimulated with r-hFSH or r-hFSH: r-hLH is strongly associated with cumulus cell derived gene expression models.\u00a0Reprod Biol Endocrinol.\u00a02025;23(163). <a href=\"https:\/\/doi.org\/10.1186\/s12958-025-01480-2\">doi:1186\/s12958-025-01480-2<\/a><\/li>\n<p><!-- \/wp:list-item --><\/p>\n<p><!-- wp:list-item --><\/p>\n<li>Van Vaerenbergh I, Adriaenssens T, Coucke W, Van Landuyt L, Verheyen G, De Brucker M, Camus M, Platteau P, De Vos M, Van Hecke E, Rosenthal A, Smitz J. Improved clinical outcomes after non-invasive oocyte selection and Day 3 eSET in ICSI patients. Reprod Biol Endocrinol. 2021;19(1):26. doi: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33608027\/\">1186\/s12958-021-00704-5<\/a><\/li>\n<p><!-- \/wp:list-item --><\/p>\n<p><!-- wp:list-item --><\/p>\n<li>Adriaenssens T, Van Vaerenbergh I, Coucke W, Segers I, Verheyen G, Anckaert E, De Vos M, Smitz J. Cumulus-corona gene expression analysis combined with morphological embryo scoring in single embryo transfer cycles increases live birth after fresh transfer and decreases time to pregnancy. J Assist Reprod Genet. 2019;36(3):433-443. doi: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30627993\/\">1007\/s10815-018-01398-2<\/a><\/li>\n<p><!-- \/wp:list-item --><\/p>\n<p><!-- wp:list-item --><\/p>\n<li>Wathlet S, Adriaenssens T, Segers I, Verheyen G, Van Landuyt L, Coucke W, Devroey P, Smitz J. Pregnancy prediction in single embryo transfer cycles after ICSI using QPCR: validation in oocytes from the same cohort. PLoS One. 2013;8(4):e54226. doi: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23573182\/\">1371\/journal.pone.0054226<\/a><\/li>\n<p><!-- \/wp:list-item --><\/p>\n<p><!-- wp:list-item --><\/p>\n<li>Wathlet S, Adriaenssens T, Segers I, Verheyen G, Janssens R, Coucke W, Devroey P, Smitz J. New candidate genes to predict pregnancy outcome in single embryo transfer cycles when using cumulus cell gene expression. Fertil Steril. 2012;98(2):432-9.e1-4. doi: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22633264\/\">1016\/j.fertnstert.2012.05.007<\/a><\/li>\n<p><!-- \/wp:list-item --><\/p>\n<p><!-- wp:list-item --><\/p>\n<li>Wathlet S, Adriaenssens T, Segers I, Verheyen G, Van de Velde H, Coucke W, Ron El R, Devroey P, Smitz J. Cumulus cell gene expression predicts better cleavage-stage embryo or blastocyst development and pregnancy for ICSI patients. Hum Reprod. 2011;26(5):1035-51. doi: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21372047\/\">1093\/humrep\/der036<\/a><\/li>\n<p><!-- \/wp:list-item --><\/p>\n<p><!-- wp:list-item --><\/p>\n<li>Adriaenssens T, Segers I, Wathlet S, Smitz J. The cumulus cell gene expression profile of oocytes with different nuclear maturity and potential for blastocyst formation. J Assist Reprod Genet. 2011;28(1):31-40. doi: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20859762\/\">1007\/s10815-010-9481-9<\/a><\/li>\n<p><!-- \/wp:list-item --><\/p>\n<p><!-- wp:list-item --><\/p>\n<li>Adriaenssens T, Wathlet S, Segers I, Verheyen G, De Vos A, Van der Elst J, Coucke W, Devroey P, Smitz J. Cumulus cell gene expression is associated with oocyte developmental quality and influenced by patient and treatment characteristics. Hum Reprod. 2010;25(5):1259-70. doi: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20228394\/\">1093\/humrep\/deq049<\/a><\/li>\n<p><!-- \/wp:list-item --><\/ol>\n<p><!-- \/wp:list --><\/p>","protected":false},"excerpt":{"rendered":"<p>Not all oocytes are equal\u2026 but now you can tell which ones will thrive The Aurora niPCT\u2122 is the first clinically proven, non-invasive test that looks at what truly matters: the oocyte\u2019s biological potential itself. By analysing the cumulus cells that naturally surround and support the egg, Aurora niPCT\u2122 decodes the molecular signals of highest &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/fertiga.com\/it\/increased-live-birth-rate-2\/\" class=\"more-link\">Leggi tutto<span class=\"screen-reader-text\"> &#8220;For healthcare providers&#8221;<\/span><\/a><\/p>","protected":false},"author":4,"featured_media":62,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-20","page","type-page","status-publish","has-post-thumbnail","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>For healthcare providers - Fertiga<\/title>\n<meta name=\"description\" content=\"Increased live birth and pregnancy rates with Aurora niPCT\u2122! 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