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Categoria: Studies

Pubblicato il
LinkedIn Post 1
February 2024

We have been published in PLOS One!

Can we use a method that “scores” eggs based on the cells surrounding them (called cumulus cells) to pick the ones most likely to lead to a successful pregnancy? This approach can help reduce the number of embryos we need to grow in the lab and limit extra embryos being frozen.

In countries where freezing embryos is restricted, analyzing these surrounding cells allows us to focus only on the eggs with the best potential. This can reduce the chance of twins, lower the lab workload, and improve overall success rates, because less promising eggs are not processed unnecessarily.

💡Learn how our Aurora Test on cumulus cells can revolutionize embryo generation in countries with legal restrictions.

Pubblicato il
LinkedIn Post 1
February 2021

We have been published in Reproductive Biology and Endocrinology!

Non-invasive oocyte quality scoring, based on cumulus gene expression analysis, in combination with morphology scoring, can increase the clinical pregnancy (CPR) and live birth rates (LBR) in Day 3 eSET (elective single embryo transfer) ICSI patients. This was first investigated in a pilot study and is now confirmed in a large patient cohort of 633 patients. It was investigated whether CPR, LBR and time-to-pregnancy could be improved by analyzing the gene expression profile of three predictive genes in the cumulus cells, compared to patients with morphology-based embryo selection only.

💡The results of our study proved that:

  • the clinical pregnancy rate (CPR) was 61% in the Aurora test arm (n = 113) compared to 29% in the control arm (n = 520,  p < 0.0001).
  • the live birth rate (LBR) in the Aurora test arm (50%) was significantly higher than in the control arm (27%, p < 0.0001).
  • the time-to-pregnancy was significantly shortened by 3 transfer cycles independent of the number of embryos available on Day 3 (Kaplan-Meier, p < 0.0001).