February 2021
We have been published in Reproductive Biology and Endocrinology!
Non-invasive oocyte quality scoring, based on cumulus gene expression analysis, in combination with morphology scoring, can increase the clinical pregnancy (CPR) and live birth rates (LBR) in Day 3 eSET (elective single embryo transfer) ICSI patients. This was first investigated in a pilot study and is now confirmed in a large patient cohort of 633 patients. It was investigated whether CPR, LBR and time-to-pregnancy could be improved by analyzing the gene expression profile of three predictive genes in the cumulus cells, compared to patients with morphology-based embryo selection only.
đź’ˇThe results of our study proved that:
- the clinical pregnancy rate (CPR) was 61% in the Aurora test arm (n = 113) compared to 29% in the control arm (n = 520,  p < 0.0001).
- the live birth rate (LBR) in the Aurora test arm (50%) was significantly higher than in the control arm (27%, p < 0.0001).
- the time-to-pregnancy was significantly shortened by 3 transfer cycles independent of the number of embryos available on Day 3 (Kaplan-Meier, p < 0.0001).